Voltage-gated Sodium Channels: Structure, Function and Channelopathies by Mohamed Chahine ISBN 9783319902838
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Voltage-gated Sodium Channels: Structure, Function and Channelopathies by Mohamed Chahine ISBN 9783319902838

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Voltage-gated Sodium Channels: Structure, Function and Channelopathies by Mohamed Chahine

Preface.- Part I.- Evolution of voltage-gated sodium channels.- 1. Evolutionary History of Voltage-Gated Sodium Channels.- 2. Mining Protein Evolution for Insights into Mechanisms of Voltage-Dependent Sodium Channel Auxiliary Subunits. - Part II. The structural basis of sodium channel function.- 3. Structural and Functional Analysis of Sodium Channels Viewed from an Evolutionary Perspective.- 4. The Cardiac Sodium Channel and Its Protein Partners.- 5.: Posttranslational Modification of Sodium Channels.- 6. Sodium Channel Trafficking.- 7. pH Modulation of Voltage-Gated Sodium Channels.- 8. Regulation of Cardiac Voltage-Gated Sodium Channel by Kinases: Roles of Protein Kinases A and C.- Part III. Drugs and toxins interactions with sodium channels.- 9. Toxins That Affect Voltage-Gated Sodium Channels.- 10. Mechanisms of Drug Binding to Voltage-Gated Sodium Channels.- 11. Effects of Benzothiazolamines on Voltage-Gated Sodium Channels.- 12. Structural Models of Ligand-Bound Sodium Channels.- 13. Selective Ligands and Drug Discovery Targeting the Voltage-Gated Sodium Channel Nav1.7.- Part IV. Pathophysiology of sodium channels.- 14. Sodium Channelopathies of Skeletal Muscle.- 15. Cardiac Arrhythmias Related to Sodium Channel Dysfunction.- 16. Translational Model Systems for ComplexSodium Channel Pathophysiology in Pain.- 17. Gating Pore Currents in Sodium Channels.- 18. Calculating the Consequences of Left-Shifted Nav Channel Activity in Sick Excitable Cells.- 19. Voltage-Gated Sodium Channel b Subunits and Their Related Diseases.

Book details

ISBN 13 9783319902838
ISBN 10 3319902830
Author Mohamed Chahine
Series Handbook Of Experimental Pharmacology
Condition New
Binding Type Hardback
Publisher Springer International Publishing AG
Year published 2018-06-14
Number of pages 450
Cover note Book picture is for illustrative purposes only, actual binding, cover or edition may vary.

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