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| Language | English |
| Format | PDF (Premium Digital) |
| Ownership | Permanent download — yours forever |
Transforming Growth Factor-Beta in Cancer Therapy, Volume II by Sonia B Jakowlew
Transforming Growth Factor-B in Cancer Therapy, Volume I: Cancer Treatment and Therapy The chapters in this volume confer an abundance of knowledge about the current state ofour understanding oftransforming growth factor-B (TGF-B) in cancer treatment and therapy. Unlike several more traditional positive polypeptide growth factors that stim- ulate cellular proliferation, the prototypical TGF-B is now known to inhibit the growth of most normal cell types, including those of epithelial and mesenchymal origin. However, there are examplesofcell types that can be stimulated by TGF-B under certain conditions. TGF-B also induces the accumulation of matrix molecules by stimulating their synthesis as well as inhibiting their degradation. Moreover, TGF-B induces apoptosis of certain cell types, thereby restricting their proliferation. OveractivityofTGF- has been linked to several diseases. For instance, the effect ofTGF- on matrix accumulation contributes to fibrotic conditions, like glomerulonephritis, lung fibrosis and liver cirrhosis (1). TGF- has a very complicated role in cancer that is only beginning to be understood.| SKU | NLS9781617377365 |
|---|---|
| ISBN 13 | 9781617377365 |
| ISBN 10 | 1617377368 |
| Author | Sonia B Jakowlew |
| Series | Cancer Drug Discovery And Development |
| Condition | New |
| Binding Type | Paperback |
| Publisher | Humana Press Inc. |
| Year published | 2010-11-19 |
| Number of pages | 786 |
| Cover note | Book picture is for illustrative purposes only, actual binding, cover or edition may vary. |
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