Your cart is empty
Have an account? Log in to check out faster.
Have an account? Log in to check out faster.
Premium PDF Edition — One-time purchase. No Kindle Unlimited subscription needed.
| Language | English |
| Format | PDF (Premium Digital) |
| Ownership | Permanent download — yours forever |
Explore The Benzodiazepines: Current Standards for Medical Practice by De Smith by De Smith, a valuable resource for readers seeking subject knowledge, key concepts, and a deeper understanding of the topic.
The Benzodiazepines: Current Standards for Medical Practice by De Smith Since their introduction to medical practice in 1960, benzodiazepines have become among the most commonly prescribed medications and have, to a great extent, replaced prescriptions of short-acting barbiturates and other sedative-hypnotics. The discovery of their psychoactive properties was almost missed. During a cleaning of their laboratory in April of 1957, Earl Reeder called to Leo Sternbach's attention several hundred milligrams of a substance and its hydrochloride salt they had synthesized in 1955 which had not been submitted for pharmacological testing. They sent the hydrochlor- ide salt, later given the generic designation of chlordiazepoxide (Librium), for animal testing to the pharmacology department, which was under the direction of Lowell Randall. Six tests, used for preliminary screening of tranquilizers and sedatives, were conducted. Dr. Randall phoned Dr. Sternbach a few days later to report that the compound possessed interesting psychotropic properties in animals (Sternback. 1983). Subse- quently over 3000 1,4 benzo-and heterodiazepines have been synthesized (Sternbach, 1983). and more is known about the mechanism of action of this class of medications than any other psychotropic drug class (Haefely, 1983). Used for treatment of anxiety. insomnia. muscle spasticity, convulsive disorders, anesthesia adjuncts and alcohol detoxification. the benzodiazepines have significant advantages over their predecessor medi- cations: the short-acting barbiturates, meprobamate and methaqualone. Of significance is their high lethal/therapeutic ratio. of importance in cases of overdose; their failure to activate liver microsomal enzymes.
Electronic edition. Please review the product details before purchase to confirm this format meets your needs.
"I was paying $11.99/month for Kindle Unlimited but realized I was renting books, not owning them. Bought this PDF and it's mine forever. Never going back to Kindle."
"Switched from Kindle to these PDFs. Same book, but I actually OWN it now. No monthly fees, no app required. Worth every penny."
"Kindle Unlimited kept raising prices. This is a one-time purchase and the file is permanently on my iPad. Best decision I've made for my reading habit."
"I compared Kindle vs this store. Kindle is cheaper monthly but you don't own anything. Here I paid once and the PDF is mine for life. Highly recommend."
"Left Kindle behind after they removed a book I was reading mid-series. With this PDF, nobody can take it away from me. True ownership feels good."
"Was skeptical about paying $18.95 when Kindle shows $3.99, but then I did the math — Kindle Unlimited is $143/year! This is way better value long term."
"Love that I can read this on any device without installing the Kindle app. The PDF works on my laptop, phone, and tablet seamlessly. So much freedom."
"My Kindle subscription was getting expensive. Switched to buying PDFs here and I'm saving money while actually building a permanent digital library I control."
"I was paying $11.99/month for Kindle Unlimited but realized I was renting books, not owning them. Bought this PDF and it's mine forever. Never going back to Kindle."
"Switched from Kindle to these PDFs. Same book, but I actually OWN it now. No monthly fees, no app required. Worth every penny."
"Kindle Unlimited kept raising prices. This is a one-time purchase and the file is permanently on my iPad. Best decision I've made for my reading habit."
"I compared Kindle vs this store. Kindle is cheaper monthly but you don't own anything. Here I paid once and the PDF is mine for life. Highly recommend."
"Left Kindle behind after they removed a book I was reading mid-series. With this PDF, nobody can take it away from me. True ownership feels good."
"Was skeptical about paying $18.95 when Kindle shows $3.99, but then I did the math — Kindle Unlimited is $143/year! This is way better value long term."
"Love that I can read this on any device without installing the Kindle app. The PDF works on my laptop, phone, and tablet seamlessly. So much freedom."
"My Kindle subscription was getting expensive. Switched to buying PDFs here and I'm saving money while actually building a permanent digital library I control."
$0
Zero monthly fees. Pay once, own forever. Unlike Kindle Unlimited at $11.99/month.
100%
True ownership. Your PDF cannot be revoked, removed, or locked behind a subscription.
Anywhere
No Kindle app required. Read on any device with any PDF reader — even offline forever.
Save
Cheaper than Amazon paperback. Better value than Kindle Unlimited long-term.