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| Language | English |
| Format | PDF (Premium Digital) |
| Ownership | Permanent download — yours forever |
Systems Pharmacology and Pharmacodynamics by Donald E Mager
While systems biology and pharmacodynamics have evolved in parallel, there are significant interrelationships that can enhance drug discovery and enable optimized therapy for each patient. Systems pharmacology is the relatively new discipline that is the interface between these two methods. This book is the first to cover the expertise from systems biology and pharmacodynamics researchers, describing how systems pharmacology may be developed and refined further to show practical applications in drug development. There is a growing awareness that pharmaceutical companies should reduce the high attrition in the pipeline due to insufficient efficacy or toxicity found in proof-of-concept and/or Phase II studies. Systems Pharmacology and Pharmacodynamics discusses the framework for integrating information obtained from understanding physiological/pathological pathways (normal body function system vs. perturbed system due to disease) and pharmacological targets in order to predict clinical efficacy and adverse events through iterations between mathematical modeling and experimentation.| ISBN 13 | 9783319830742 |
|---|---|
| ISBN 10 | 3319830740 |
| Author | Donald E Mager |
| Series | Aaps Advances In The Pharmaceutical Sciences Series |
| Condition | New |
| Binding Type | Paperback |
| Publisher | Springer International Publishing AG |
| Year published | 2018-07-04 |
| Number of pages | 511 |
| Cover note | Book picture is for illustrative purposes only, actual binding, cover or edition may vary. |
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