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| Language | English |
| Format | PDF (Premium Digital) |
| Ownership | Permanent download — yours forever |
Superantigens by Bernhard Fleischer
This volume of Current Topics in Microbiology and Immunology is concerned with a class of molecules that are the most potent polyclonal stimulators of T lymphocytes of several species. These molecules have been named superantigens because they use a mechanism of T cell stimulation closely mimicking MHC-restricted recognition of specific antigen: they act on variable parts of T cell antigen receptors and are presented by MHC class I molecules. Prototypes of these molecules are the pyrogenic exotoxins produced by S. aureus and S. pyogenes, of which the staphylococcal enterotoxins and the toxic shock syndrome toxin are the best known. Superantigens also occur endogen- ously in mice, most notably the enigmatic Mis determinants, that have withstood characterization for nearly 20 years. Only very recently was it found that Mis is probably encoded by endogenous retroviruses. The list of candidates that are implicated as being superantigens is growing. In many cases, however, the proof that a given molecule indeed falls into this category is still missing.| ISBN 13 | 9783642510007 |
|---|---|
| ISBN 10 | 3642510000 |
| Author | Bernhard Fleischer |
| Series | Current Topics In Microbiology And Immunology |
| Condition | New |
| Binding Type | Paperback |
| Publisher | Springer |
| Year published | 2012-05-26 |
| Number of pages | 137 |
| Cover note | Book picture is for illustrative purposes only, actual binding, cover or edition may vary. |
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