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| Language | English |
| Format | PDF (Premium Digital) |
| Ownership | Permanent download — yours forever |
Recent Advances in Transthyretin Evolution, Structure and Biological Functions by Samantha J Richardson
Since its ?rst description in 1942 in both serum and cerebrospinal ?uid, transthyretin (TR) has had an eventful history, including changes in name from prealbumin to thyroxine-binding prealbumin to transthyretin as knowledge increased about its functions. TR is synthesised in a wide range of tissues in humans and other eutherian mammals: the liver, choroid plexus (blood- cerebrospinal ?uid barrier), retinal pigment epithelium of the eye, pancreas, intestine and meninges. However, its sites of synthesis are more restricted in other vertebrates. This implies that the number of tissues synthesising TR during vertebrate evolution has increased, and raises questions about the selection pressures governing TR synthesis. TR is most widely known as a distributor of thyroid hormones. In addition, TR binds retinol-binding protein, which binds retinol. In this way, TR is also involved with retinoid distribution. More recently, TR has been demonstrated to bind a wide variety of endocrine disruptors including drugs, pollutants, industrial compounds, heavy metals, and some naturally occurring plant ?avonoids. These not only interfere with thyroid hormone delivery in the body, but also transport such endocrine disruptors into the brain, where they have the potential to accumulate.| ISBN 13 | 9783642420719 |
|---|---|
| ISBN 10 | 3642420710 |
| Author | Samantha J Richardson |
| Condition | New |
| Binding Type | Paperback |
| Publisher | Springer |
| Year published | 2014-11-05 |
| Number of pages | 362 |
| Cover note | Book picture is for illustrative purposes only, actual binding, cover or edition may vary. |
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