RAS Family GTPases by Channing Der ISBN 9781402043284
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RAS Family GTPases by Channing Der ISBN 9781402043284

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RAS Family GTPases by Channing Der

Since 1982, Ras proteins have been the subject of intense research investigation by the biomedical research community. The wide interest in Ras has been stimulated for three key reasons.

First, their frequent mutational activation in human cancers establishes Ras proteins as important mediators of oncogenesis and targets for anti-cancer drug discovery. Second, Ras proteins act as signalling nodes activated by diverse extracellular stimuli, and activated Ras in turn regulates a diversity of cytoplasmic signalling networks. Third, Ras proteins are founding members of a large superfamily of Ras-related small GTPases. Over 150 Ras-related small GTPases are found in the human genome, with orthologs found in all vertebrate species and invertebrates.

This book features chapters by leading investigators in the field that highlight the current state-of-the art in Ras biochemistry, structure and biology. This book is an excellent reference for students in the biomedical sciences and for investigators in the field.

Book details

SKU NLS9781402043284
ISBN 13 9781402043284
ISBN 10 1402043287
Author Channing Der
Series Proteins And Cell Regulation
Condition New
Binding Type Hardback
Publisher Springer-Verlag New York Inc.
Year published 2006-09-13
Number of pages 397
Cover note Book picture is for illustrative purposes only, actual binding, cover or edition may vary.

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