{"product_id":"proteases-in-gastrointestinal-tissues-by-uwe-lendeckel","title":"Proteases in Gastrointestinal Tissues by Uwe Lendeckel | ISBN-13 9789048171347","description":"\u003cp\u003e\u003cb\u003eProteases in Gastrointestinal Tissues by Uwe Lendeckel\u003c\/b\u003e\u003c\/p\u003e\n This, the fifth volume in the Proteases in Biology and Disease series, is devoted to Proteases in Gastrointestinal Tissues. Of course, proteases play an important role in the digestion and utilization of ingested proteins, but besides that they elicit a wide range of physiological and pathological effects. Proteases have been recognized as essential regulators, acting both locally and systemically, of normal development, growth and functioning. Dysregulation of protease expression and\/or enzymatic activity is often associated with the onset or progression of disease and, thus, proteases represent interesting targets for the pharmacological therapy of e. g. cancer, chronic inflammation, graft rejection, fibrosis, diabetes, vascular disease, and viral or bacterial infections. In addition, changes in the localization, abundance or activity of proteases may serve as informative diagnostic or prognostic markers. This volume focuses on stomach, gut, pancreas, and liver and highlights the role of proteases in normal physiology and disease processes involving these tissues. The first chapter by Nigel W. Bunnett and Graeme S. Cottrell reviews the current knowledge about the protease-activated receptors (PARs) in gastrointestinal tissues. Starting with the mechanisms of activation, signal transduction, and regulation of PAR, their role in controlling gastrointestinal functions and the possible involvement in gastrointestinal diseases are summarized. In Chapter 2, Nikhil I. Khushalani and Nithya Ramnath review the role of matrix metalloproteases (MMPs) and their natural inhibitors, TIMPs, in different types of gastric cancer.\u003ch3\u003eBook details\u003c\/h3\u003e\u003ctable style=\"border-collapse:collapse;width:100%;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;padding:6px 10px;border:1px solid #ddd;\"\u003eISBN 13\u003c\/th\u003e\n\u003ctd style=\"padding:6px 10px;border:1px solid #ddd;\"\u003e9789048171347\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;padding:6px 10px;border:1px solid #ddd;\"\u003eISBN 10\u003c\/th\u003e\n\u003ctd style=\"padding:6px 10px;border:1px solid #ddd;\"\u003e9048171342\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;padding:6px 10px;border:1px solid #ddd;\"\u003eAuthor\u003c\/th\u003e\n\u003ctd style=\"padding:6px 10px;border:1px solid #ddd;\"\u003eUwe Lendeckel\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;padding:6px 10px;border:1px solid #ddd;\"\u003eSeries\u003c\/th\u003e\n\u003ctd style=\"padding:6px 10px;border:1px solid #ddd;\"\u003eProteases In Biology And Disease\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;padding:6px 10px;border:1px solid #ddd;\"\u003eCondition\u003c\/th\u003e\n\u003ctd style=\"padding:6px 10px;border:1px solid #ddd;\"\u003eNew\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;padding:6px 10px;border:1px solid #ddd;\"\u003eBinding Type\u003c\/th\u003e\n\u003ctd style=\"padding:6px 10px;border:1px solid #ddd;\"\u003ePaperback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;padding:6px 10px;border:1px solid #ddd;\"\u003ePublisher\u003c\/th\u003e\n\u003ctd style=\"padding:6px 10px;border:1px solid #ddd;\"\u003eSpringer\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;padding:6px 10px;border:1px solid #ddd;\"\u003eYear published\u003c\/th\u003e\n\u003ctd style=\"padding:6px 10px;border:1px solid #ddd;\"\u003e2010-11-16\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;padding:6px 10px;border:1px solid #ddd;\"\u003eNumber of pages\u003c\/th\u003e\n\u003ctd style=\"padding:6px 10px;border:1px solid #ddd;\"\u003e344\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth style=\"text-align:left;padding:6px 10px;border:1px solid #ddd;\"\u003eCover note\u003c\/th\u003e\n\u003ctd style=\"padding:6px 10px;border:1px solid #ddd;\"\u003eBook picture is for illustrative purposes only, actual binding, cover or edition may vary.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"Springer","offers":[{"title":"Default Title","offer_id":67682412232949,"sku":"9789048171347","price":39.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0795\/8632\/8821\/files\/9789048171347.jpg?v=1791826912","url":"https:\/\/arbiyas.com\/products\/proteases-in-gastrointestinal-tissues-by-uwe-lendeckel","provider":"Arbiyas","version":"1.0","type":"link"}