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| Language | English |
| Format | PDF (Premium Digital) |
| Ownership | Permanent download — yours forever |
Prostaglandin E1 by Curt Diehm
Although prostaglandin El (PGE ) has been clinically available for a long 1 time, only in recent years has its effectiveness in peripheral arterial occlusive disease been confirmed in controlled studies. Not surprisingly, the favour- able results achieved both in patients with critical limb ischaemia and in those with intermittent claudication has stimulated research activities into the clinical pharmacology of this prostaglandin. As a consequence of these efforts, exciting new findings have revealed that PGE has anti thrombotic, endothelium-stabilizing and leucocyte-stabi- 1 lizing properties as well as effects on lipid metabolism, all of which, quite apart from its well-known anti-aggregating and vasodilator effects, may add to the clinical efficacy of the substance. New data have also been gathered on the metabolism of PGE most b notably the detection of 13, 14-dihydro-PGE a metabolite which was b recently isolated in humans following the administration of PGE. Being 1 biologically active, the pharmacodynamic spectrum of 13, 14-dihydro-PGE 1 very closely resembles that of PGE. This finding may help to explain the 1 efficacy of PGE despite its rapid metabolization when given intravenously.| SKU | NLS9783540545248 |
|---|---|
| ISBN 13 | 9783540545248 |
| ISBN 10 | 3540545247 |
| Author | Curt Diehm |
| Condition | New |
| Binding Type | Paperback |
| Publisher | Springer |
| Year published | 1992-01-20 |
| Number of pages | 117 |
| Cover note | Book picture is for illustrative purposes only, actual binding, cover or edition may vary. |
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"Was skeptical about paying $18.95 when Kindle shows $3.99, but then I did the math — Kindle Unlimited is $143/year! This is way better value long term."
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