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| Language | English |
| Format | PDF (Premium Digital) |
| Ownership | Permanent download — yours forever |
Pharmacology of Intestinal Permeation I by W Mcd Armstrong
The intestine, particularly the small bowel, represents a large surface (in the adult 2 human approximately 200m ) through which the body is exposed to its environment. A vigorous substrate exchange takes place across this large surface: nutrients and xenobiotics are absorbed from the lumen into the bloodstream or the lymph, and simultaneously, the same types of substrate pass back into the lumen. The luminal surface of the intestine is lined with a leaky epithelium, thus the passage of the substrates, in either direction, proceeds via both transcellular and intercellular routes. Simple and carrier-mediated diffusion, active transport, pinocytosis, phagocytosis and persorption are all involved in this passage across the intestinal wall. The term intestinal permeation refers to the process of passage of various substances across the gut wall, either from the lumen into the blood or lymph, or in the opposite direction. Permeability is the condition of the gut which governs the rate of this complex two-way passage. The pharmacologist's interest in the problem of intestinal permeation is twofold: on the one hand, this process determines thebioavailability of drugs and contributes significantly to the pharmacokinetics and toxicokinetics of xeno- biotics; on the other hand, the pharmacodynamic effects of many drugs are manifested in a significant alteration of the physiological process of intestinal permeation.| ISBN 13 | 9783642695070 |
|---|---|
| ISBN 10 | 3642695078 |
| Author | W Mcd Armstrong |
| Series | Handbook Of Experimental Pharmacology |
| Condition | New |
| Binding Type | Paperback |
| Publisher | Springer |
| Year published | 2012-06-04 |
| Number of pages | 708 |
| Cover note | Book picture is for illustrative purposes only, actual binding, cover or edition may vary. |
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