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Premium PDF Edition — One-time purchase. No Kindle Unlimited subscription needed.
| Language | English |
| Format | PDF (Premium Digital) |
| Ownership | Permanent download — yours forever |
Optimizing the "Drug-Like" Properties of Leads in Drug Discovery by Ronald Borchardt
Drug discovery and development is a very complex, costly, and ti- consuming process. Because of the uncertainties associated with predicting the pharmacological effects and the toxicity characteristics of new chemical entities in man, their clinical development is quite prone to failure. In recent years, phar- ceutical companies have come under increasing pressure to introduce new blockbuster drugs into the marketplace more rapidly. Companies have responded to these pressures by introducing new technologies and new strategies to expedite drug discovery and development. Drug discovery and development have traditionally been divided into three separate processes (i. e., discovery research, preclinical development, and clinical development) that ideally should be integrated both organizationally and functionally. Instead, separate and distinct discovery research, preclinical development, and clinical development divisions were created within many companies during the 1980s and 1990s, Because of their isolation, scientists in the discovery research divisions often were advancing drug candidates into preclinical development that had marginal drug-like properties. For the purpose of this presentation, drug-like properties refer to the molecule's physicochemical, absorption-distribution-metabolism-excretion (ADME), and toxicological properties. Lacking optimal drug-like properties often caused these drug candidates to fail in preclinical or clinical development.| SKU | NLS9780387340562 |
|---|---|
| ISBN 13 | 9780387340562 |
| ISBN 10 | 0387340564 |
| Author | Ronald Borchardt |
| Series | Biotechnology: Pharmaceutical Aspects |
| Condition | New |
| Binding Type | Hardback |
| Publisher | Springer-Verlag New York Inc. |
| Year published | 2006-08-03 |
| Number of pages | 512 |
| Cover note | Book picture is for illustrative purposes only, actual binding, cover or edition may vary. |
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