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| Language | English |
| Format | PDF (Premium Digital) |
| Ownership | Permanent download — yours forever |
New Trends in Macromolecular and Supramolecular Chemistry for Biological Applications by Marc Jm Abadie
This contributed volume applies the insights of supramolecular chemistry to biomedical applications such as ions/water transport through nano-scale channels, gene therapy, tissue engineering and drug delivery, to cite some of the major investigations.The challenge is to understand the mechanisms of transport through tissues particularly in the therapeutic treatment of a disease where the active drug must be delivered directly to diseased cells without affecting healthy cells. As a result, smaller quantities of active substances can be used to treat the disease. Another interest concerns new ways to administer gene therapy. If genes are often delivered to their target cells by adapted viruses, the supramolecular non-viral ‘vectors’ using dynamic nano-frameworks and nano-structures are presented. In addition, it is important to reconstruct damaged tissues by mimicking natural processes in cells and polymers, such as tissue engineering and self-healing. Differentoptions are here discussed: e.g. hydrogels based on chitosan, a carbohydrate polymer, are proving especially promising for tissue engineering and drug delivery. For controlled delivery of drugs or other biologically active compounds, hydrogels sensitive to the most important stimuli in the human body, such as temperature, pH, ionic strength, glucose and biomolecules released by the organism in pathological conditions have been developed. Finally, to assist and validate the experimental studies, computer modelling and simulations of large-sized molecular structures and systems using different molecular dynamics and quantum mechanical techniques are developed based on the experimental and chemistry synthesis.| SKU | NLS9783030574581 |
|---|---|
| ISBN 13 | 9783030574581 |
| ISBN 10 | 303057458X |
| Author | Marc Jm Abadie |
| Condition | New |
| Binding Type | Paperback |
| Publisher | Springer Nature Switzerland AG |
| Year published | 2022-05-29 |
| Number of pages | 371 |
| Cover note | Book picture is for illustrative purposes only, actual binding, cover or edition may vary. |
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