Natural Products as Antiviral Agents by Ck Chu ISBN 9781461365099
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Natural Products as Antiviral Agents by Ck Chu ISBN 9781461365099

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Natural Products as Antiviral Agents by Ck Chu

During the past fifty years, thousands of natural products have been isolated from plants, fungi, and bacteria. Apart from intense searches by pharmaceutical companies for medicinals and the concentrated effort mounted by the National Cancer Institute, many of these have not been tested in biological systems. The major reasons for this appear to be, at least, twofold. First, individual researchers looking for biologically active natural products will often isolate only small amounts of material sufficient to determine a structure and calculate the specific activity for their particular bioassay systems: insufficient funds preclude re-isolating the compound unless industrial potential is foreseen. Second, the difficulty with which original structures were proved prior to 1972. This required the isolation of relatively large quantities of a natural product and there followed extensive degradation, elemental analyses of the parent and its fragments, then synthesis, piece by piece, of the molecule. All this took time and energy. No wonder that when the structure was proved the chemist was enervated. And coupled to this was the fact that many chemists were not trained to test their materials in biological systems. In contrast, today a natural product can be isolated, its mass and molecular formula determined and, if there is some serendipity, crystals may be obtained for single crystal x-ray analysis. If conditions are near perfect, it is possible to isolate and identify a novel compound in a month.

Book details

SKU NLS9781461365099
ISBN 13 9781461365099
ISBN 10 1461365090
Author Ck Chu
Condition New
Binding Type Paperback
Publisher Springer-Verlag New York Inc.
Year published 2012-10-28
Number of pages 279
Cover note Book picture is for illustrative purposes only, actual binding, cover or edition may vary.

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