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| Language | English |
| Format | PDF (Premium Digital) |
| Ownership | Permanent download — yours forever |
Homocysteine and Vascular Disease by K Robinson
This is an important and timely volume. The history of research in homocysteine metabolism can be divided into three periods. The first phase was the exploration of the individual reactions and metabolites that characterize the transmethylation and transsulfuration sequences. The former originated with his description of the biosynthesis of methylpyridine and culminated in the work of Cantoni and Axelrod. Similarly the finding that insulin contained cystine was a potent catalyst for the metabolic and nutritional studies of Rose and du Vigneaud. The description and the definition of homocystinuria, a rare inherited meta- bolic disorder, marked the beginning of the second historical period. Where previously there had been few laboratories located largely in the United States soon there were numerous research groups representing many nationalities. The more intense focus led to major advances, both in the laboratory and in the clinics. Studies of afflicted individuals, when combined with investigations in experimental animals, provided the basis for a concept of methionine metabo- lism that encompassed both transmethylation and transsulfuration. The central role of homocysteine was apparent.| ISBN 13 | 9789048154319 |
|---|---|
| ISBN 10 | 9048154316 |
| Author | K Robinson |
| Series | Developments In Cardiovascular Medicine |
| Condition | New |
| Binding Type | Paperback |
| Publisher | Springer |
| Year published | 2010-12-04 |
| Number of pages | 448 |
| Cover note | Book picture is for illustrative purposes only, actual binding, cover or edition may vary. |
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