Histamine in Inflammation by Robin Thurmond ISBN 9781441980557
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Histamine in Inflammation by Robin Thurmond ISBN 9781441980557

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Histamine in Inflammation by Robin Thurmond

The year 2010 marks the centennial for the identification of histamine and the first glimpse of its many physiological functions. From these initial findings a rich tapestry of research has uncovered roles for histamine in almost every physiological process with new findings emerging every year. These diverse roles of histamine have made for fertile ground for the discovery of novel therapeutics, and these drugs have been so successful that the term antihistamine has entered the common lexicon. This volume is an attempt to give a snapshot in time as to the current understanding of the role of histamine in just one important therapeutic area--inflammation. The first three chapters provide some background context for the rest of the book starting out with a historical perspective by Figueroa and Shankley. Bongers et al provide an overview of the pharmacology of the four histamine receptors and the chapter by Hiroshi Ohtsu describes how histamine is synthesized as well as the insights derived from mice where this synthesis is disrupted. The next several chapters discuss disease areas where histamine is known to be involved. Chapter 4 by Thomas Taylor-Clark outlines the role of histamine in allergic rhinitis, an area were antihistamines are commonly used. This is also true for ocular allergy as discussed by Ohbayashi et al. Both of these chapters highlight aspects of these conditions that are still not well-controlled and suggest the utility of new antihistamines targeting other histamine receptors.

Book details

SKU NLS9781441980557
ISBN 13 9781441980557
ISBN 10 1441980555
Author Robin Thurmond
Series Advances In Experimental Medicine And Biology
Condition New
Binding Type Hardback
Publisher Springer-Verlag New York Inc.
Year published 2010-12-16
Number of pages 143
Cover note Book picture is for illustrative purposes only, actual binding, cover or edition may vary.

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