Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection by Alexzander Aa Asea | ISBN-13 9789048178131
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Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection by Alexzander Aa Asea | ISBN-13 9789048178131

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Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection by Alexzander Aa Asea

With the prevalence of neurodegenerative diseases on the rise as average life expectancy increases, the hunt for effective treatments and preventive measures for these disorders is a pressing challenge. Neurodegenerative disorders such as Alzheimer's disease, Huntington's disease, Parkinson's disease and amyotrophic lateral sclerosis have been termed 'protein misfolding disorders' that are char- terized by the neural accumulation of protein aggregates. Manipulation of the cellular stress response involving the induction of heat shock proteins offers a the- peutic strategy to counter conformational changes in neural proteins that trigger pathogenic cascades resulting in neurodegenerative diseases. Heat shock proteins are protein repair agents that provide a line of defense against misfolded, aggregati- prone proteins. Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection reviews current progress on neural heat shock proteins (HSP) in relation to neurodegenerative diseases (Part I), neuroprotection (Part II), ext- cellular HSP (Part III) and aging and control of life span (Part IV). Key basic and clinical research laboratories from major universities and hospitals around the world contribute chapters that review present research activity and importantly project the field into the future. The book is a must read for researchers, postdoctoral fellows and graduate students in the fields of Neuroscience, Neurodegenerative Diseases, Molecular Medicine, Aging, Physiology, Pharmacology and Pathology.

Book details

ISBN 13 9789048178131
ISBN 10 9048178134
Author Alexzander Aa Asea
Series Heat Shock Proteins
Condition New
Binding Type Paperback
Publisher Springer
Year published 2010-10-28
Number of pages 373
Cover note Book picture is for illustrative purposes only, actual binding, cover or edition may vary.

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