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| Language | English |
| Format | PDF (Premium Digital) |
| Ownership | Permanent download — yours forever |
Gastrointestinal Regulatory Peptides by Sm O'grady
Since the discovery of the pancreatic secretagogue secretin by W. M. BAYLIS and E. H. STARLING at the inception of the twentieth century, intense interest has focused on numerous, continually expanding classes of small peptides which appear to serve as regulatory molecules in the gastrointestinal tract, brain, and other organ systems. Initially, many of these substances were, like secretin, discovered in functional assays as factors or activities extractable in minute quantities from tissues or tissue fluids. By the middle of the century, advances in biochemical and immunological methods for the purification, characterization, and quantification of biologically active peptides in organ systems, tissues, and body fluids provided further impetus to this field. It was readily appreciated that small, biologically active peptides were particularly abundant in the digestive tract. Many peptides such as vasoactive intestinal peptide, gastrin, and more recently peptide Y and galanin were in fact originally discovered in and isolated from gut tissue. Moreover, these peptides were found to have profound actions on the gastroenteropancreatic system in vivo and in vitro. During the past 2 decades, information on regulatory peptides has burgeoned as a result of technological refinements in the synthesis of peptides, improved methods for detecting and visualizing peptides and their precursors in cells and tissues from a variety of species, advances in the functional assessment of peptide activity, and the application of molecular biological techniques to the char- acterization of peptide gene structure and expression.| ISBN 13 | 9783642778162 |
|---|---|
| ISBN 10 | 364277816X |
| Author | David R Brown |
| Series | Handbook Of Experimental Pharmacology |
| Condition | New |
| Binding Type | Paperback |
| Publisher | Springer |
| Year published | 2011-12-16 |
| Number of pages | 446 |
| Cover note | Book picture is for illustrative purposes only, actual binding, cover or edition may vary. |
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