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| Language | English |
| Format | PDF (Premium Digital) |
| Ownership | Permanent download — yours forever |
DNA Repair and Mutagenesis in Eukaryotes by W Generoso
Not many years ago most discussion of mutation induction by physical and chemical agents concentrated on the initial lesions induced in the DNA with the implicit assumption that once the lesions were made they were converted almost automatically to mutations by relatively simple processes associated with DNA replication. The discovery of a variety of enzymatic processes that can repair these lesions, the great increase in our understanding of the molecular steps involved in repair, replication, and recombination, and the increasing availability of cells with genetic defects in these pro- cesses have led to the realization that mutation induction is a far more complex process than we originally thought. Repair systems can remove lesions before they can be converted to mutation, they can also convert initial lesions to secondary ones that are them- selves mutagenic, and they can remove potentially lethal lesions at the expense of making mutations. The error-avoiding systems asso- ciated with replication are themselves complex and may be caused to make mistakes in various ways. These different pathways for mutation production and mutation avoidance are still being worked out in prokaryotes and are less well understood in eukaryotes. This symposium shows, however, that very encouraging progress has been made in the last several years, and the progress is now accelerating.| SKU | NLS9781468438444 |
|---|---|
| ISBN 13 | 9781468438444 |
| ISBN 10 | 1468438441 |
| Author | W Generoso |
| Series | Basic Life Sciences |
| Condition | New |
| Binding Type | Paperback |
| Publisher | Springer-Verlag New York Inc. |
| Year published | 2012-06-14 |
| Number of pages | 458 |
| Cover note | Book picture is for illustrative purposes only, actual binding, cover or edition may vary. |
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"Left Kindle behind after they removed a book I was reading mid-series. With this PDF, nobody can take it away from me. True ownership feels good."
"Was skeptical about paying $18.95 when Kindle shows $3.99, but then I did the math — Kindle Unlimited is $143/year! This is way better value long term."
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