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| Language | English |
| Format | PDF (Premium Digital) |
| Ownership | Permanent download — yours forever |
Disordered Vertebral and Rib Morphology in Pudgy Mice by Frederic Shapiro
This book presents results obtained from the whole mount preparations, radiological, and histological studies of 60 pu/pu and pu/+ mice from late embryo until 3 months of age. Most mice were in the embryo to 6 week age group where vertebral developmental changes are most marked. Although vertebral abnormalities have been identified as due to mutations in the delta-like 3 (Dll3) gene, it is evident that each mouse has differing structural abnormalities. The disorder is analogous to human congenital scoliosis, a common variant of which is spondylocostal dysplasia. The histological studies presented in this book include plastic embedded sections which allow for high level resolution not only of vertebrae, intervertebral discs, and ribs but also of associated spinal cord, nerve roots and ganglia. In addition an overview of embryo and neonatal development in mouse, chick and human vertebrae is provided to better assess how and where deviant pathoanatomy occurs. The book discusses the possible variables involved in creating final deformity beyond the gene abnormality itself.| ISBN 13 | 9783319431499 |
|---|---|
| ISBN 10 | 3319431498 |
| Author | Frederic Shapiro |
| Series | Advances In Anatomy Embryology And Cell Biology |
| Condition | New |
| Binding Type | Paperback |
| Publisher | Springer International Publishing AG |
| Year published | 2016-09-30 |
| Number of pages | 123 |
| Cover note | Book picture is for illustrative purposes only, actual binding, cover or edition may vary. |
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"Left Kindle behind after they removed a book I was reading mid-series. With this PDF, nobody can take it away from me. True ownership feels good."
"Was skeptical about paying $18.95 when Kindle shows $3.99, but then I did the math — Kindle Unlimited is $143/year! This is way better value long term."
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