Cellular and Molecular Mechanisms in Hypertension by Robert H Cox ISBN 9781468460179
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Cellular and Molecular Mechanisms in Hypertension by Robert H Cox ISBN 9781468460179

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Cellular and Molecular Mechanisms in Hypertension by Robert H Cox

Hypertension is recognized to be one of the major risk factors for the development of peripheral vascular disease. The last decade has witnessed several major advances in therapy for hypertension, including the development of angiotensin-converting enzyme inhibitors and calcium channel blockers. These compounds have greatly improved the ability to control blood pressure and to reduce the impact of this risk factor on morbidity and mortality. In spite of these advances, cardiovascular disease remains a major health problem in most modern industrialized countries with related deaths exceeding those from all other causes combined. In contrast to these advances in therapy, our understanding of the basic mechanisms responsible for the pathogenesis of hypertension remains incomplete. Recent studies have produced new insights into the nature of the regulation of muscle contraction in both heart and blood vessels as well as the changes in muscle function that occur in hypertension. However, the effects of antihypertensive therapy, both in terms of restoring normal function and in producing reversal of hypertension-associated changes, has not been as thoroughly studied, especially in the vasculature. Studies in the heart suggest that the efficacy of different therapeutic agents in restoring normal function and reversing hypertensive changes vary substantially with the mechanism of action of the therapeutic agent. It has also been recently determined that some therapeutic agents produce adverse effects on plasma lipid profiles, which could lead to the secondary acceleration of the atherosclerotic process, while at the same time normalizing blood pressure.

Book details

SKU NLS9781468460179
ISBN 13 9781468460179
ISBN 10 146846017X
Author Robert H Cox
Series Advances In Experimental Medicine And Biology
Condition New
Binding Type Paperback
Publisher Springer-Verlag New York Inc.
Year published 2012-03-23
Number of pages 264
Cover note Book picture is for illustrative purposes only, actual binding, cover or edition may vary.

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