Cancer Stem Cells by Otmar D Wiestler | ISBN-13 9783642420863
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Cancer Stem Cells by Otmar D Wiestler | ISBN-13 9783642420863

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Cancer Stem Cells by Otmar D Wiestler

Cancer stem cells werehave originally been identified in leukemia and later in several solid tumor types. They have very different properties from the bulk of the tumor, as they divide much more slowly and have very efficient drug- resistance mechanisms. Current treatments might largely spare cancer stem cells, thus leading to tumor recurrence and metastasis. The recent identification of growth and differentiation pathways responsible for cancer stem cell proliferation and survival will help in the discovery identification of novel therapeutic targets. Developing selective drugs against cancer stem cells offers great therapeutic opportunities but also provides for major challenges regarding preclinical models, therapeutic windows, and clinical study end points.

Book details

ISBN 13 9783642420863
ISBN 10 3642420869
Author Otmar D Wiestler
Series Ernst Schering Foundation Symposium Proceedings
Condition New
Binding Type Paperback
Publisher Springer
Year published 2014-11-28
Number of pages 263
Cover note Book picture is for illustrative purposes only, actual binding, cover or edition may vary.

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