{"product_id":"cancer-cell-lines-part-1-by-john-masters","title":"Cancer Cell Lines Part 1 by John Masters | ISBN-13 9789401738248","description":"\u003cp\u003eExplore \u003cstrong\u003eCancer Cell Lines Part 1 by John Masters\u003c\/strong\u003e by John Masters, a valuable resource for readers seeking subject knowledge, key concepts, and a deeper understanding of the topic.\u003c\/p\u003e\u003cp\u003eCancer Cell Lines Part 1 by John Masters Continuous cell lines derived from human cancers are the most widely used resource in laboratory-based cancer research. The first 3 volumes of this series on Human Cell Culture are devoted to these cancer cell lines. The chapters in these first 3 volumes have a common aim. Their purpose is to address 3 questions of fundamental importance to the relevance of human cancer cell lines as model systems of each type of cancer: 1. Do the cell lines available accurately represent the clinical presentation? 2. Do the cell lines accurately represent the histopathology of the original tumors? 3. Do the cell lines accurately represent the molecular genetics of this type of cancer? The cancer cell lines available are derived, in most cases, from the more aggressive and advanced cancers. There are few cell lines derived from low grade organ-confined cancers. This gap can be filled with conditionally immortalized human cancer cell lines. We do not know why the success rate for establishing cell lines is so low for some types of cancer and so high for others. The histopathology of the tumor of origin and the extent to which the derived cell line retains the differentiated features of that tumor are critical. The concept that a single cell line derived from a tumor at a particular site is representative of tumors at that site is naive and misleading.\u003c\/p\u003e\u003ch3\u003eBook details\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eISBN-13:\u003c\/strong\u003e 9789401738248\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAuthor:\u003c\/strong\u003e John Masters\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePublisher:\u003c\/strong\u003e Springer\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePublication year:\u003c\/strong\u003e 2013\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePages:\u003c\/strong\u003e 293\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eElectronic edition. Please review the product details before purchase to confirm this format meets your needs.\u003c\/p\u003e","brand":"Springer","offers":[{"title":"Default Title","offer_id":67681960034549,"sku":null,"price":39.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0795\/8632\/8821\/files\/9789401738248.jpg?v=1791822635","url":"https:\/\/arbiyas.com\/products\/cancer-cell-lines-part-1-by-john-masters","provider":"Arbiyas","version":"1.0","type":"link"}